Can you die using marijuana? The simple answer is no. You cannot die with any amount of cannabis alone. There are ways to have unpleasant highs. Technically speaking, the bodily receptors that regulate a weed high are not located in the brainstem — meaning they cannot possibly cause an overdose. Though the buzz of cannabis can be intolerable to some, the drug is not lethal. However, there are certain instances where complications, injury, and even death can occur during a weed high. There have been deaths associated with marijuana, not caused by it. Here are some ways too much weed can cause uncomfortable, and potentially lethal, experiences.